Steroids, such as prednisolone, have been shown to be effective in managing some kidney disorders, such as nephrotic syndrome, and following transplantation. Unfortunately, they can have side effects.
Named after the Canadian physician who first noted the effect, there is a tendency for the cheeks and stomach to increase in size, whilst the limbs become thin. Some patients develop facial hair and the face is flushed. Appetite may increase. Fortunately, most of these side effects improve if the drug can be reduced.
A common effect of long term use of steroids is osteoporosis, thinning of the bones. It is suggested that HRT after the menopause may help but this is not yet proven. New drugs on the market claim to control, or even improve, bone loss, but they must be used with caution where there is renal impairment.
AVN (avascular necrosis) is a distressing condition of the joints, especially the hips. Pain on walking can vary from mild to severe, uncontrolled by painkillers. Replacement of hip, knee and shoulder joints have very good results.
A few patients may find they have raised blood pressure and there is a tendency to diabetes, particularly if there is a family history to this condition. Some patients find they have mood changes, a state of euphoria especially post-transplant when high doses of steroids may be used. Reducing the dose may be helpful in these circumstances.
NKF Controlled Document No. 86, Side effects of Steroids, written 28 June 1999. Last reviewed 10 March 2008.
The National Kidney Federation cannot accept responsibility for information provided. The above is for guidance only. Patients are advised to seek further information from their own doctor.
Page created: 28 June 1999
Last updated: 18 July 2007
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