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About your medicine

Prednisolone is a steroid tablet. It is not the same type of steroid tablet that body builders take. It is used to protect your new kidney against rejection.

Whilst you are taking prednisolone you are more likely to become ill due to an infection, especially during periods of stress. It is advisable to report any infection to your doctor.

You should NOT be vaccinated with some vaccines whilst receiving prednisolone. (Vaccines are injections that can be given to help prevent you from catching some diseases, for example, polio). For vaccines you can and cannot have, see the vaccine page.

If you or anyone in your family or close friends catches CHICKENPOX it is important to tell your doctor IMMEDIATELY but DO NOT STOP taking your prednisolone. It is also important that you contact your doctor if you catch chickenpox within three months of stopping prednisolone.

Taking your Medicine

You should swallow the tablets whole with a glass of water. They are best taken with food first thing in the morning.

Take the tablets exactly as your doctor explained to you. Do not suddenly stop taking the tablets. Your doctor will tell you when to reduce the dose and when to stop altogether.

If you forget to take a dose, take it as soon as you remember, unless it is nearly time to take the next dose then go on as before.

You will lose your new kidney if you stop taking the prednisolone tablets.

Unwanted effects

Like most medicines, prednisolone can cause side effects in some people. These include indigestion, weight gain, moon face, bloatedness, tiredness. Effects that may be seen over a longer period of time include thinning of the bones and skin (and bruising on the arms and legs), high blood pressure and mood changes.

If you suffer from any of these, or other undesirable effects, report them to your doctor. DO NOT stop taking the tablets. Your doctor will have chosen this treatment for you bearing in mind the above risks and the risks to you from rejecting your kidney.

Storing your medicine

Store all your tablets in their original containers, in a cool dry place out of the reach of children. You should only remove them from the bottle/box when it is time to take them.

NKF Controlled Document No. 76, Prednisolone for Transplant, written 22 April 2000. Last reviewed 10 March 2010.


The National Kidney Federation cannot accept responsibility for information provided. The above is for guidance only. Patients are advised to seek further information from their own doctor.


The National Kidney Federation is registered in England and Wales as a Company limited by guarantee (Company No 5272349)
and awarded charitable status (Charity Number 1106735).

Give as You Earn contributions No. CAF GY511.

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Page created: 22 April 2000

Last updated: 14 January 2010

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